Novel vaccination approaches based on rational design of B- and T-cell epitopes – epitope-based vaccines – are making progress in […]
Epitope-based vaccines (EVs) make use of short antigen-derived peptides corresponding to immune epitopes, which are administered to trigger a protective humoral and/or […]
Background: Peptide vaccination based on multiple T-cell epitopes can be used to target well-defined ethnic populations. Because the response to […]
Alloimmunization is an adverse effect of blood transfusions. In Chile, alloimmunization frequency is not established, and for this reason the […]
Multiple sclerosis (MS) is the principal cause of autoimmune neuroinflammation in humans, and its animal model, experimental autoimmune encephalomyelitis (EAE), […]
The role of interferon (IFN)-γ in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), has remained as […]
Pneumococcal infections are a public health concern, especially among older adults and those with underlying comorbid or immunocompromising conditions. In […]
B-cell receptor (BCR) engagement with surface-tethered antigens leads to the formation of an immune synapse, which facilitates antigen uptake for […]
Dopamine receptors have been described in T-cells, however their signalling pathwayscoupled remain unknown. Since cAMP and ERKs play key roles regulating T-cellphysiology, we aim to determine whether cAMP […]
