Centro Investigación en Educación Superior

Control de la ingesta alimentaria: rol del receptor 4 de melanocortina en el desarrollo de obesidad

Licencia Creative Commons Reconocimiento CC BY. Esta obra está bajo una Licencia Creative Commons Reconocimiento CC BY 4.0 Internacional.

Arquate nucleus, a convergence site of peripheral and central signals, plays a fundamental role in the control of food intake. Orexigenic neurons that secrete neuropeptide Y (NPY) and Agouti-related peptide (AgRP) and anorexigenic neurons secreting Pro-opiomelanocortin (POMC) are involved in this action. Both groups of neurons respond to peripheral signals such as insulin and leptin and are reciprocally inhibited. α Type melanocyte stimulating hormone (αMSH), liberated by POMC neurons, reduces food intake activating melanocortin receptor 4 (MC4R), located in second order neurons of the paraventricular nucleus. NPY/AgRP antagonize the effects of this peptide on MC4R receptors, maintaining an inhibitory tone on αMHS liberation, mediated by the activation of gabaergic receptors of POMC neurons. The study of these mechanisms will allow the development of new medications, especially MC4R agonists, to reduce nutrient intake.

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